Serum Markers for Septicemia Research Paper Example | Topics and Well Written Essays - 2500 words

Serum Markers for Septicemia - Research Paper Example It is clear that a single biomarker which is ideal though has not been identified but a series specific studies on individual pathogen mediated sepsis has been studied extensively,. Challenges that are faced during biomarker research lied in the lack of uniform protocol and methodology , standardization of the assays and the detection levels to be fixed age wise from population to population. The reliable detection of Biomarkers can be useful to have a immense diagnostic and prognostic relevance in relation to the management of sepsis. Sepsis is considered as the most important cause of morbidity and mortality. By sepsis we mean infection of the blood and if it is caused by bacteria we term it as bacteremia and if by virus it is termed viremia. As such the infection in the blood is not so dangerous but as blood perfuses the important tissues and organs infections can be carried by blood to the kidneys or lungs which can result in the end organ failures of a patient leading to death i n severe conditions. The main issue is that sepsis often lacks clinical manifestations so if the specific and the sensitive indicators of the infections are collected and analyzed then it will create superior out comes in the management of the disease. Immunologically it can be considered as the dysregulation of the response of the innate immune system. Biomarkers are hence important to signal the presence and severity of sepsis in early conditions for effective prognostic values and importance.(Chiesa,1998)(De Bont,1994)(Manroe,1979)(Squire,1979). It is very important to note that sepsis is not a true disease and just a physiological manifestation of the systemic immune response in innate immunity majority of the studies define sepsis to be a systemic inflammatory response to a bacteria, virus or fungi. In clinical setting several other physiological symtoms must be presented to properly diagnose sepsis. The common treatments of patients suspected with sepsis aims to eradicate the bacteria in the blood or reduce its growth by using broad spectrum antimicrobials. The gold standard of sepsis diagnosis has been traditionally the use of microbial cultures to identify the source of illness. The major limitation of using cultures in the length of the time required to develop cultures to identifiable quantities to detect sepsis and the possible icrobes to start the treatment with antimicrobials and this with Bactek culture takes around 48 hours and hence there is a need of early detection through the detection of serum biomarkers which thus becomes important. Even the cultures might be insensitive under several conditions including the slow growing and non cultivatable organisms present at very low concentrations . So in the light of this problem alternative diagnostic methods using molecular biology tool kits have been developed to address the situation for rapid and automated detection of sepsis. These tests are basically the ELISA tests, flow cytometric detection of the specific marker antigens,immunocolorimetric tests ,FISH methodologies and PCR and amplified PCR techniques and the main ideology was to detect the marker proteins. In parallel to the development of biomarkers which provides a faster and more sensitive diagnostic methods for infectious microbes thus relies on the monitoring of the changes in specific serum protein biomarker concentrations. Biomarker is best defined as a factor or feature that can

Strategy Management and Health Information Technology Essay

Strategy Management and Health Information Technology - Essay Example As will be discussed in the preceding sections, this level of organic growth was most heavily impacted with regards to the acquisition of several key firms that offered software and logistics solutions with regards to the application of EMR (Goodwin et al, 2013). Finally, the current business seeking to broaden upon the way in which the Canadian health system integrates with and understands/utilizes electronic medical records. This is of course something of a gamble as it cannot be definitively determined which direction the health and governmental organizations that control the system might develop. Nonetheless, this is a gamble that Telus Health has been willing to take. Telus Business Strategy: As with any firm, Telus Health is most supremely interested in maximizing profits. Likewise, in order to affect such an end, it is necessary for the firm to grow into new markets, integrate with new products, and gain a higher level of customers/sales. Although there are many means to affec t such an end, the particular business strategy that Telus Health has chosen to engage with can most definitively be described as one of acquisition. An acquisition strategy is a strategy that many firms/organizations would doubtless love to be able to pursue. However, there is a costly requirement in order to pursue such an end. Generally, firms that pursue an acquisition strategy have excess capital in reserve. In order to do this, it is necessary for the firm to of experienced a large degree of success in the past or to have assets that it is willing to leverage in order to affect such a strategy. A small company with extra capital may use an acquisition strategy to gain a competitive advantage. An acquisition strategy entails purchasing another company, or one or more product lines of that company. For example, a small grocery retailer on the east coast may purchase a comparable grocery chain in the Midwest to expand its operations. As the reader can see, the acquisition of KinL ogix, MD Practice Software LP, and Wolf EMR have all served to underscore the level and extent to which the firm is leveraging the strategy of acquisition in order to boost profits. Explanation of Telus Health broader objectives In order to gain a larger share of profitability, firms generally seek to make gambles with regards to what direction they believe the industry is moving towards (Business Policy and Strategy, 2010). Accordingly, many times such gambles pay off. Conversely, many firms see their profits and viability wither and died based upon incorrect calculations of future markets in the direction to which current trends are pointing. Likewise, Telus Health has made a significant gamble with regards to the current market and prospects of the way in which the Canadian healthcare system will integrate with EMR. As such, the reader can see that Telus Health has come to the understanding that EMR will dominate the Canadian healthcare system in the near future. Accordingly, Tel us Health desperately wants to be part of the transformation by acquiring as many EMR firms that coalesce with its mission and desired future mission as possible. This is done as